Blood–Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease

Journal article

B. Lin, Sandeepa Sur, Peiying Liu, Yang Li, Dengrong Jiang, B. Hou, Jacqueline A. Darrow, J. Pillai, S. Yasar, P. Rosenberg, M. Albert, A. Moghekar, Hanzhang Lu
Annals of Neurology, 2021

Semantic Scholar DOI PubMedCentral PubMed

Cite

APA Click to copy
Lin, B., Sur, S., Liu, P., Li, Y., Jiang, D., Hou, B., … Lu, H. (2021). Blood–Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease. Annals of Neurology.

Chicago/Turabian Click to copy
Lin, B., Sandeepa Sur, Peiying Liu, Yang Li, Dengrong Jiang, B. Hou, Jacqueline A. Darrow, et al. “Blood–Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease.” Annals of Neurology (2021).

MLA Click to copy
Lin, B., et al. “Blood–Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease.” Annals of Neurology, 2021.

BibTeX Click to copy

@article{b2021a,
  title = {Blood–Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease},
  year = {2021},
  journal = {Annals of Neurology},
  author = {Lin, B. and Sur, Sandeepa and Liu, Peiying and Li, Yang and Jiang, Dengrong and Hou, B. and Darrow, Jacqueline A. and Pillai, J. and Yasar, S. and Rosenberg, P. and Albert, M. and Moghekar, A. and Lu, Hanzhang}
}

Abstract

Blood–brain barrier (BBB) breakdown has been suggested to be an early biomarker in human cognitive impairment. However, the relationship between BBB breakdown and brain pathology, most commonly Alzheimer disease (AD) and vascular disease, is still poorly understood. The present study measured human BBB function in mild cognitive impairment (MCI) patients on 2 molecular scales, specifically BBB's permeability to water and albumin molecules.