Association between basal forebrain and medial temporal lobe tau, and gray matter volume

Journal article

A. Shafer, Maiya F. MacAlpine, Cristina Bañuelos, A. Moghekar, Susan M. Resnick, Murat Bilgel
Alzheimer's & Dementia, 2023

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APA Click to copy
Shafer, A., MacAlpine, M. F., Bañuelos, C., Moghekar, A., Resnick, S. M., & Bilgel, M. (2023). Association between basal forebrain and medial temporal lobe tau, and gray matter volume. Alzheimer's &Amp;Amp; Dementia.

Chicago/Turabian Click to copy
Shafer, A., Maiya F. MacAlpine, Cristina Bañuelos, A. Moghekar, Susan M. Resnick, and Murat Bilgel. “Association between Basal Forebrain and Medial Temporal Lobe Tau, and Gray Matter Volume.” Alzheimer's & Dementia (2023).

MLA Click to copy
Shafer, A., et al. “Association between Basal Forebrain and Medial Temporal Lobe Tau, and Gray Matter Volume.” Alzheimer's &Amp;Amp; Dementia, 2023.

BibTeX Click to copy

@article{a2023a,
  title = {Association between basal forebrain and medial temporal lobe tau, and gray matter volume},
  year = {2023},
  journal = {Alzheimer's &amp; Dementia},
  author = {Shafer, A. and MacAlpine, Maiya F. and Bañuelos, Cristina and Moghekar, A. and Resnick, Susan M. and Bilgel, Murat}
}

Abstract

Tau pathology is a hallmark of Alzheimer’s disease (AD). The basal forebrain (BF) is a significant cholinergic projection site with cholinergic groups 1‐3 (Ch1‐3) projecting to the hippocampus, hypothalamus, and olfactory bulb, and group 4 (Ch4) projecting to the cortical mantle and amygdala. Braak stage 1 includes BF tau and recent literature suggests BF degeneration precedes medial temporal lobe (MTL) degeneration, thus implicating early involvement of the BF in AD. This study examines BF 18F‐flortaucipir (FTP) retention and gray matter (GM) volume, and their associations with MTL FTP retention and GM volume.