APA
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Parikh, S. K., Deline, C., McCreary, M., Amoozegar, F., Amrhein, T., Carroll, I. R., … Friedman, D. I. (2025). The contribution of lumbar puncture opening pressure in the diagnosis of spontaneous intracranial hypotension: A systematic literature review and meta-analysis. Headache.
Chicago/Turabian
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Parikh, Simy K, C. Deline, Morgan McCreary, F. Amoozegar, T. Amrhein, Ian R Carroll, J. Cutsforth-Gregory, et al. “The Contribution of Lumbar Puncture Opening Pressure in the Diagnosis of Spontaneous Intracranial Hypotension: A Systematic Literature Review and Meta-Analysis.” Headache (2025).
MLA
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Parikh, Simy K., et al. “The Contribution of Lumbar Puncture Opening Pressure in the Diagnosis of Spontaneous Intracranial Hypotension: A Systematic Literature Review and Meta-Analysis.” Headache, 2025.
BibTeX Click to copy
@article{simy2025a,
title = {The contribution of lumbar puncture opening pressure in the diagnosis of spontaneous intracranial hypotension: A systematic literature review and meta-analysis.},
year = {2025},
journal = {Headache},
author = {Parikh, Simy K and Deline, C. and McCreary, Morgan and Amoozegar, F. and Amrhein, T. and Carroll, Ian R and Cutsforth-Gregory, J. and Leithe, Linda G and Kranz, Peter F and Louy, Charles and Maya, Marcel M. and Moghekar, A. and Rau, Jill C. and Silberstein, Stephen and Schievink, Wouter I. and Friedman, Deborah I.}
}
OBJECTIVE The objective of this study was to summarize the available evidence regarding the clinical value and trend over time of lumbar cerebrospinal fluid (CSF) opening pressure utilization to diagnose spontaneous intracranial hypotension (SIH).
BACKGROUND CSF opening pressure obtained via lumbar puncture is one of the diagnostic criteria for SIH based on the International Criteria for Headache Disorders, 3rd Edition (ICHD-3), but it has questionable utility as an initial investigation for diagnosing SIH.
METHODS The authors performed a systematic literature review and meta-analysis. PubMed/MEDLINE, Scopus, and Cochrane Library were searched from inception to October 2022. Original studies and case series in English reporting three or more patients with suspected or known SIH and CSF pressure measurement were included. Meta-analyses and meta-regression were used to calculate pooled estimates and examine the impact of age, sex, and publication year on outcomes, including CSF pressure < 60 mm CSF, orthostatic headache, and positive findings on brain magnetic resonance imaging (MRI), spinal imaging, and radionuclide studies.
RESULTS For every 1-year increase in the year of publication, the odds of reporting low CSF pressure decreased by 6.20% (adjusted odds ratio [aOR] = 0.94, aOR 95% confidence interval [CI] = [0.90, 0.97], p = 0.001), the odds of reporting a positive brain MRI increased by 4.67% (aOR = 1.05, aOR 95% CI = [1.01, 1.09], p = 0.026), and the odds of reporting orthostatic headache increased by 9.13% (aOR = 1.09, aOR 95% CI = [1.03, 1.15], p = 0.002). Each 1% increase in the percentage of patients with orthostatic headache was associated with a 3.13% increase in the odds of low CSF pressure (aOR = 1.03, aOR 95% CI = [1.01, 1.05], p = 0.003). Similarly, as the percentage of patients with low CSF pressure increased by 1%, there was a 2.53% increase in the odds of orthostatic headache (aOR = 1.03, aOR 95% CI = [1.01, 1.04], p = 0.005). It was estimated that 31.9% of patients with SIH had normal opening pressure (95% CI = [24.0%, 40.8%], prediction interval = [5.0%, 80.5%]). Every 1% increase in the percentage of patients with positive brain MRI was associated with a 5.25% increase in the odds of positive spinal imaging (aOR = 1.05, aOR 95% CI = [1.00, 1.11], p = 0.047). Age and positive radionuclide study did not significantly impact the outcomes measured. The corresponding I2 for each outcome was reduced by controlling for study-wide covariates believed to impact the prevalence of each outcome. Sensitivity analyses did not reveal discrepancies in results when studies requiring outcomes of interest were removed.
CONCLUSION Our analysis found that recent studies indicate a reduced reliance on opening pressure for diagnosing SIH. Rather, results suggest an increasing reliance on contrast-enhanced brain MRI, spine imaging, and clinical features for SIH diagnosis.